Hormones and Health
Thursday, August 16th, 2007By Donna DiMarco
Hormones are a hot topic these days since the Women’s Health Initiative cut off their study before it was complete (after 5 years-instead of the planned
due to overwhelming evidence that PremPro, a Premarin/progestin hormone replacement therapy, caused increased incidence of breast cancer, heart disease and strokes.
As a result of all the media attention, many women have stopped their hormone replacement therapy (HRT) in search of a safer, more natural method of avoiding hot flashes, night sweats, vaginal dryness, and all the other lovely symptoms of menopause. Hopefully, the days of blindly trusting the doctor to prescribe something to make us quickly feel better is behind us and women will be better informed so that they can play a part in deciding what risks, if any, to take regarding hormone replacement. The body does need a perfect balance of hormones to function properly, but at what cost? And should hormone-like substances be substituted for the real thing?
Estrogen is produced mainly in the ovaries, but some is also made in the adrenal glands; minor amounts are produced in other places as well. The ovaries also produce progesterone in the corpus luteum (the ruptured sac on the ovary from which an egg has erupted). Since we are born with a finite number of eggs and have been releasing one each month throughout our lives, the supply diminishes near menopause. Without the ruptured sac to produce a sufficient amount of progesterone, we become estrogen dominant. Unopposed estrogen (without progesterone) increases our chances of breast cancer. Also, the proper ratio (estradiol to progesterone) is important in preventing hot flashes and other menopause symptoms, not just the lack of estrogen. And most importantly, synthetic progestin won’t do.
More women have estrogen dominance than you would imagine, but many of them are given estrogen anyway. And, unfortunately, those who need progesterone are given progestin instead. Progestin is synthetic progesterone created in a laboratory to mimic the real McCoy. The molecular structure of progestin is just a tiny bit different than natural progesterone, just different enough to allow it to be patented and to make lots of money for the pharmaceutical companies. You see, most hormones start with a molecular structure similar to that found in the component of soy or wild yam; it’s called diosgenin. (It’s for this reason that soy helps with hot flashes) This molecule can be manipulated to conform to the structure of the hormone being prepared, not just progesterone, but others as well. If this molecule is identical to that found in the body (bio-identical) it cannot be patented since it is a natural substance, but if it is similar, yet with a unique structure, drug companies can name it, patent it, and rake in the bucks—providing it doesn’t cause obvious damage. These synthetic hormone structures look so much like the real hormones that they are able to enter the receptor sites and imitate some of the hormone’s functions within the body. But the body is not easily fooled and will eventually respond, often with disease. That’s what has happened with the hormone replacement therapy (HRT) in this study. Here are some differences in natural progesterone vs. synthetic progestin.
Progestins: increases sodium and water retention in body cells and cause loss of mineral electrolytes from cells, cause depression, Increase risk of birth defect, cause facial hair, cause thrombophlebitis, embolism risk, decrease glucose tolerance and cause allergic reactions
Progesterone: Protects against endometrial and ovarian cancer, normalizes libido, reduces facial hair while stimulating re-growth of scalp hair, improves lipid profile and new bone formation (progesterone is better than the drugs recommended for osteoporosis), decreases risk of coronary vasospasm, helps thyroid hormone action, eases symptoms of PMS, is essential for myelinization of nerves, restores normal sleep patterns, is a precursor of other steroid hormones, and is essential also male health.
Which would you rather have, the decision is truly yours? The Women’s Health Initiative Study used progestin along with Premarin, which is (pregnant mare’s urine) horse estrogen, not human. Ah, ah, ah! You can’t fool Mother Nature! She fights back. They tried to fool the body into thinking it had what it needed, instead it provoked serious responses– heart disease, cancer and stroke. The sad part of this story is that the same diosgenin can easily be converted into bio-identical progesterone- the kind the body can use. It is readily available in many of the creams sold in health food stores and is used by alternative practitioners with great success.
Medical doctors are solicited by the drug company reps; they are given gifts and incentives, provided with pre-printed prescription pads and lots of free samples, in order to promote the sale of the pharmaceuticals. It’s big business. Women often feel that if the doctor recommended a drug, it must be what’s best. As someone who acts as a consultant to medical doctors, that isn’t always the case. I have met many doctors who didn’t even know the difference between progesterone and progestins. In doctor’s defense, many of them are so overwhelmed with keeping up with the latest advances in their specialty that they have little time for in-depth study, so they accept the erroneous information they are fed (often by the drug companies. How many years have they been recommending Prem-Pro? Remember Fen-Phen? What about Thalidomide?).
What can you do? Take control of your own health. Become empowered with knowledge to make intelligent decisions as to how your healthcare progresses. Take the time to learn about alternative methods. The body has the uncanny ability to heal itself if given the materials to do so. Learn how to give it what it needs.
One of the best ways to empower yourself is to read any of the books by Dr. John R. Lee, M.D. John is most noted for his dedication to teaching medical doctors about the difference between natural and synthetic hormones. His books include : “What Your Doctor May Not Tell You About Menopause”, or “…Peri Menopause”, and his latest “…Breast Cancer”. Susan Love, Betty Kamen and Christine Northrup are also good providers of reliable information about women’s health issues.
Your next step should be to test your hormone levels. This could be done by a simple saliva test without a prescription (except for New York and California). Saliva is used instead of blood because it measures the free form hormone, that which is not bound to protein but available to do its work. Blood tests measure bound hormone only.
Check with your health practitioner or go to www.salivatest.com and check out what ZRT Labs has to offer. They will send you a simple collection kit so you can spit in a tube first thing in the morning and mail it to them with a check. Your results will be returned with an explanation of what it means.
Now comes the hard part, take your results to a practitioner who can help you balance your hormones naturally. Your practitioner can have a compounding pharmacy make up any combination of NATURAL estrogens or progesterone. Your prescription should be based on you and your hormone levels as well as your clinical information; it should not be a cookie-cutter formula handed out to all equally. This should be done only AFTER exploring all pathways to find out why you are not producing the hormones yourself. Often it is a simple remedy and HRT is not needed.
Diet is important. Try to give your body what it needs to make hormones naturally. Essential fatty acids are important to hormone production so forget the fat free diets, instead, consume nuts, seeds, avocado, olive oil, salmon, mackerel, etc. Small amounts of soy can help with symptoms. Please don’t over do it since studies link soy to other complications. Avoid dairy, since cows are often given hormones to maintain milk production. Eat plenty of cruciferous vegetables for their ability to encourage “good” hormone ratios.
Avoid plastics and pesticides whenever possible. They too have a similar structure to estrogen (xenoestrogens) and are linked to breast cancer (some studies have also linked them to homosexual behavior in animals, hmmm!). Avoid tight-fitting bras, especially with under wires. Some believe that the restriction of lymphatic flow can cause breast cancer; no bra is best.
Always check your breasts monthly and have an annual exam at your gynecologist. Be sure to have a baseline mammogram, but remember that x-rays CAUSE cancer, so don’t be too quick to have your breasts irradiated too often. Early detection is NOT prevention or protection. If they detect it, it’s too late–you got it already.
Take cancer-fighting supplements- antioxidants and a multi vitamin-mineral to make up for what may be lacking in the diet. Let your body do its job. We all have abnormal cells in our bodies. But if we help our bodies’ function at optimum level, it will destroy those cells. If it has to spend all its energy detoxifying junk food and toxins, it has hindered ability to keep us healthy. Give it a try, health is easier to attain than you think. Just care enough about yourself to do it.
Donna